Small Spreads of Breast Cancer May Not Affect Survival

Small Spreads of Breast Cancer May Not Affect Survival

Cr7 shoes collection cr7 shoes sale wednesday, Jan. 19 cr7 shoes sale (HealthDay News) For decades, doctors have debated about how to best determine whether a patient breast cancer has spread, especially in the earliest cases of metastases.Now, researchers have compared two approaches a sentinel lymph node biopsy alone, or the sentinel biopsy cr7 shoes collection combined with axillary dissection, which is a more invasive procedure that can spot hidden, smaller metastases. The finding: As long as the larger metastases (2 millimeters in diameter and up) are found, the outcomes of the two procedures are similar. Donald L. Weaver, a professor of pathology at the University of Vermont College of Medicine and Vermont Cancer Center. The report is published in the Jan. 19 online edition of the New England Journal of Medicine.Weaver and his team randomly assigned 5,611 women with breast cancer but clinically negative axillary nodes to one of two groups about half underwent the sentinel node biopsy alone and the cr7 shoes sale other half underwent the biopsy plus axillary dissection.A sentinel lymph node is the first lymph node to which cancer is likely to spread. cr7 shoes collection The biopsy is based on the idea that cancer cells metastasize in an orderly fashion.At cr7 shoes sale the centers participating in the study, the sentinel node exam was designed to find all metastases more than 2 millimeters in dimension, known as macrometastases.Followup data was available for 1,924 in the combination group and 1,960 in the biopsyonly group. In the biopsyonly group, 300 were positive for metastases, while 316 were positive in the combination group.The researchers looked at differences in the patients in whom the hidden metastases were found and in those in which they weren found. They compared overall survival, diseasefree survival and distantdiseasefree survival.you had them, the [overall] survival was 94.6 percent; if not, 95.8. There only a 1.2 percent difference between the two, Weaver said.While the difference was significant from a statistical point of view, it was slight from a clinical point of view, he noted.For women, Weaver said, the takehome message is not to be concerned about metastases being missed, provided the sentinel lymph node biopsy was done.is enough as long as you find the macrometastases, the ones over 2 millimeters, he said.As for the smaller spreads? are probably being treated by whatever cancer treatment is recommended [for the primary tumor], he said, such as chemotherapy, endocrine therapy or radiation.The new information of solidifies an idea that we know, said Dr. Laura Kruper, an assistant professor of oncology and a breast cancer surgeon at the City of Hope Comprehensive Cancer Center in Duarte, Calif.What the findings suggest, she said, is that the standard procedure followed by many do the sentinel lymph node biopsy alone if it negative seems to be effective.She added, however, that really do need to continue to follow these patients longterm to see if the differences remain small cr7 shoes sale.